HORDB

ID: hor005264
Uniprot ID: Q7M427
Protein name: Egg-laying hormone
Gene name: NA
Organism: Aplysia fasciata (Mottled sea hare) (Aplysia brasiliana)
Family: molluscan ELH family
Source: animal
Expression: Bag cell neurons.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: ELH acts as a neurotransmitter locally, upon neurons of the abdominal ganglion and as a hormone by diffusing into the circulating hemolymph and modulating the activity of other organs. It specifically causes contraction of smooth muscle in the ovotestis and expulsion of the egg string.
Mechanism: NA
Cross BBB: NO
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q7M427-F1.pdb

hor005264_AF2.pdb

hor005264_ESM.pdb

Mass:	500961	Formula:	C190H328N58O58S
Absent amino acids:	CFGHPVW	Common amino acids:	L
pI:	9.25	Basic residues:	7
Polar residues:	5	Hydrophobic residues:	13
Hydrophobicity:	-61.67	Boman Index:	-10968
Half-Life:	20 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	124.72
Instability Index:	3291.67	Extinction Coefficient cystines:	1490
Absorbance 280nm:	42.57

PubMed ID: 3226961
Title: The bag cell egg-laying hormones of Aplysia brasiliana and Aplysia californica are identical.